How often do you say “no” to things that would interfere with your goals?

I say ‘no’ to all the things that interfere with my goals but unfortunately as they are work and my health, I am not in a position to act on the ‘no’.
I’m allergic to starving and being homeless so I have to say ‘yes’ to work even though it interferes with my goal of working on my own business – there aren’t enough hours in the day.
My health is rubbish, but I can’t really say ‘no’ to a chronic illness. I can say ‘not today’ and fight through it, but the fact is that it’s the biggest ‘no’ in my life.
So I say ‘no’ daily. But it becomes ‘yes’ because I have no option.